Predictive Models for Early Detection of Glaucoma using Electronic Health Records

Glaucoma is the second leading cause of irreversible blindness across the world. Around 70 million people have glaucoma, and 4.4 million people are blind due to undiagnosed glaucoma by optic nerve damage worldwide. Studies suggest that early detection of glaucoma…

Analysis of tumor associated macrophages’ heterogeneity in colorectal cancer patients using single-cell RNA-seq data

Colorectal cancer (CRC) is one of the deadliest malignancies worldwide. Though immune checkpoint inhibition has proven effective for a number of other tumors, it offers benefits in only a small group of CRC. In general, heterogenous cell groups in the…

EXPLAINABLE ARTIFICIAL INTELLIGENCE FOR PATIENT STRATIFICATION AND DRUG REPOSITIONING

Enabling precision medicine requires developing robust patient stratification methods as well as drugs tailored to homogeneous subgroups of patients from a heterogeneous population. Developing de novo drugs is expensive and time consuming with an ultimately low FDA approval rate. These limitations make…

Scientific illustrations as a source of biological pathway information

The idea of cross-referencing distinct areas of knowledge to glean new insights is not new, but not much work has been done with automatic analysis of different expressions of the same knowledge source, such as a given scientific text and…

Synteny and compositional domains in honey bee genomes

Analysis of synteny, the conservation of gene order between homologs along chromosome segments, is a standard investigative strategy done in many comparative genomic studies to understand genomic conservation and evolution. It allows us to study the evolutionary history between genomes.

A Case-Control based Genomic Analysis of Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease (COPD) is a respiratory illness that affects millions of people all over the world. It is a major cause of chronic morbidity and mortality and a serious global public health problem. COPD is the fourth leading…

Large Scale Study of the Long-Term Effects of COVID-19 Infection Using Aggregated EHR Data

COVID-19 is known to have complex multi-system effects but the lasting effects of infection remain poorly understood. With the number of confirmed infections globally surpassing 200 million it is more important than ever to understand the potential long-term implications of…

FASTAptameR 2.0: A Web Server for Combinatorial Selections Analysis

Combinatorial selection strategies are powerful tools that allow researchers to simulate selective pressures over time on randomized sequence libraries. This is important for lead discovery and optimization and for understanding selection dynamics. Given the evolutionary nature of these experiments, high-fitness…

Bioinformatics Research and Collaboration in the Era of Big Data and Precision Medicine

As we have entered the precision medicine and big data science era, there are many unmet challenges on identifying the disease related information from large, heterogeneous data, and translating the findings for clinical use. Among these challenges, one is how…