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MUIDSI DISSERTATION DEFENSE: Explainable Artificial Intelligence To Stratify Pan-Cancer Patients For Immune Checkpoint Inhibitor Decision Making

Immune checkpoints are a normal part of the immune system. It engages when proteins on the surface of immune cells called T cells recognize and bind to partner proteins on other cells, such as some tumor cells. Immune based therapies such as ICIs work by blocking checkpoint proteins from binding with their partner proteins. This

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Overhead imagery training data quality control: Methods for deep feature label anomaly detection

Spatial analysis of large remotely-sensed imagery (RSI) training datasets for within-class variation and between-class separability is key to uncovering issues of data diversity and potential bias, not just when vetting datasets for usage, but also during the actual dataset creation stage. Project managers of complex imagery annotation campaigns have a largely unaddressed need for tools that continuously

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Biological pathways as graphs: comparison of select similarity methods

We extracted biomedical pathways from 47 publications related to non-small cell lung cancer (NSCLC) and mergedthem into a Neo4j graph database. With this graph serving as ground truth for comparing to other pathways that were extracted from other publications, we investigated several methods of calculating graph similarity. Unlike ontologies and engineered data sets that have uniform representations of data objects, graphs extracted from unstructured texts haveto be compared as text-described entities first, and by using common graph similarity methods second. In this work, we discuss ways of comparing biological graphs composed of text-described

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MUIDSI Comprehensive Exam — Measuring Geodiversity in Remotely-Sensed Imagery: Deep Spatial Change Detection Methods for Dataset Bias Mitigation and Visual Landscape Characterization

Amid explosive growth in availability of multimodal remotely sensed imagery (RSI) data from a constellation of overhead sensors, a lack of understanding persists concerning the actual content of these data sources, in particular the nature of spatial variation in the visual and contextual features in the landscape being imaged. Whether described as spatial domain shift,

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GIScience as an Interdisciplinary Bridge in Indigenous Health Equity 

GIS and geographic theories can help bridge a crucial gap in interdisciplinary research projects. Geography is uniquely poised to offer critical and practical analytical support, wrangle spatial data and relate them to other datasets, and ground community-based science within the communities it aims to serve. In the context of the Navajo Nation, a key concern

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Impact of diabetes status and other factors on risk for thrombotic and thromboembolic events: A multicenter, retrospective analysis using the Cerner Real-World DataTM de-identified COVID-19 cohort 

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a proinflammatory condition that can impact the cardiovascular and cerebrovascular systems, thereby increasing risk for thrombotic and thromboembolic events (TTE). However, little is known about the impact of diabetes status on risk for TTEs during SARS-CoV-2 infection. In this US-based, multicenter

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Analysis of polygenic selection in purebred and crossbred pig genomes using Generation Proxy Selection Mapping

Background Artificial selection on quantitative traits using selection indices in commercial livestock breeding populations causes changes in allele frequency over time, termed selection signatures, at causal loci and other surrounding genomic regions.  Researchers and managers of pig breeding programs are motivated to understand the genetic basis of phenotypic diversity across genetic lines, breeds, and populations using

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Comprehensive Exam: Using subgroup discovery techniques to identify a high-risk group of suicide attempts among people with diabetes

In 2019, 37.3 million Americans had diabetes mellitus, and 1.2 million Americans aged 18 and older had attempted suicide in the past year. According to previous studies, people with type 1 diabetes were three to four times more likely to attempt suicide, and newly diagnosed with type 2 diabetes were two times more likely to

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Detecting formation and growth of refugee / displaced person camps in the Ukraine crisis: Assisting first-phase humanitarian response using satellite imagery

Amid the worst population displacement crisis in Europe since World War 2, governments and international organizations have struggled with the massive task of tracking and providing aid to Ukrainian refugees and internally displaced persons (IDPs). This presentation reviews requirements and explores solutions for AI-assisted monitoring of formation of ad-hoc refugee encampments and temporary/informal settlements in

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A Computational Respiration Factor to Detect Abnormal Respiratory Patterns Using a Hydraulic Bed Sensor for Older Adults Aging-in-place

Hydraulic bed sensors are efficient non-wearable, passive sensors for unobtrusive and continuous collection of health data for older adults aging-in-place. Continuous collection of data can speak volumes about onset and development of a disease much before it is diagnosed and that is our vision through this work. Hydraulic bed sensor data yields signal from which

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