T cells are instrumental in orchestrating cell-mediated adaptive immunity by their unique ability to recognize antigens via T cell receptors (TCRs) and initiate downstream immune responses. TCRs exhibit an astonishing degree of variability, surpassing numbers of T cells within an individual. However, only a minute fraction of T cells possesses the capacity to recognize a…

In recent years, the prowess of large language models (LLMs) like ChatGPT by OpenAI has garnered immense attention, not just for their raw computational abilities, but also for their potential as surrogate knowledge graphs. Trained on a plethora of data sources, ranging from peer-reviewed research articles to the vast swathes of the web, these models…

Cancer is a major cause of global mortality, necessitating accurate long-term survival (LTS) predictions for patients to optimize treatment strategies and improve prognosis. The advent of high-throughput technologies has facilitated the study of biological systems through multiple omics data, including genomics, transcriptomics, proteomics and other omics. Consequently, multi-omics approaches have emerged as promising tools for…

The widespread adoption of consumer sensor technologies, including wearable and in-home sensors, present an opportunity for ambient monitoring of activities of daily living for health and behavioral intervention. Health care professionals (i.e., care coordinators trained as nurses, occupational therapists, and social workers) in the Age-friendly Sustainable Smart and Equitable Technologies for Access for Aging in…