Regulation of gene expression by DNA methylation with cytotoxic T lymphocytes evaluation in consensus molecular subtypes of colorectal cancer
Background: Low cytotoxic T lymphocyte (CTLs) infiltration in colorectal cancer (CRC) tumors is a challenge to treatment with immune checkpoint inhibitors. Consensus molecular subtypes (CMS) classify patients based on tumor attributes, and CMS1 patients include the majority of patients with…
Leveraging Unsupervised Machine Learning To Find Trends In The Textual Warnings Generated Using Multi-Modality Time Series Sensor Data
With technology and the internet of things (IoT), smart health care is no longer a dream. The devices that wouldn’t usually be generally expected to have an internet connection can communicate with the network independent of human action, and this…
Information Extraction Framework for Facilitating the Assessment of the Quality of Radiology Interpretations
Assessing the quality of imaging interpretations requires that the results of radiological interpretations be compared with those of subsequent surgical-pathology results, when available. The manual process is inherently slow, tedious and expensive, and unless systematic errors occur in the interpretations,…
Abnormal liver function and adverse health outcomes in COVID-19: A multicenter, retrospective analysis of 14,872 patients from the Cerner Real-World DataTM de-identified COVID-19 cohort
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been associated with liver impairment and abnormalities in liver function tests. However, associations between hepatic impairment and patient health outcomes have not been well-studied in large cohorts. In…
Thyroid Cancer Informatics
Survival prediction is important both to clinicians and patients; ensuring the best course of treatment is selected to manage the thyroid cancer. In 2018, there was an estimated half a million new thyroid cancer diagnoses and 41,071 deaths. Unlike other tumors whose…
A Case-Control based Genomic Analysis of Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease (COPD) is a respiratory illness that affects millions of people all over the world. It is a major cause of chronic morbidity and mortality and a serious global public health problem. COPD is the fourth leading…
Methods for Measuring Geodiversity in Large Overhead Imagery Datasets
This research introduces some of the first geo-computational methods to address a key gap in the artificial intelligence (AI) and big data literature as it relates to the geosciences and remote sensing: the lack of understanding of the global feature…
The Genescape Allele Catalog Development for Precise Identification of Causative SNPs
Next-generation sequencing (NGS) has become more popular in the modern-day. Large amounts of next-generation resequencing data have been generated and are available online for various organisms including soybeans. However, current genome-wide association study (GWAS) prediction tools simply identify the most…
Evaluating the effectiveness of transfer-learning with DeepVariant
Genomic data has become ubiquitous for bioinformaticians; however, successfully inferring biological meaning depends upon the sensitive prediction of differences between genomes. The most popular method to infer short sequence variants is the Genome Analysis Toolkit (GATK). While GATK provides rigorous…