Risk Factors for Thyroid Cancer, a Systematic Review
Thyroid cancer accounted for 1 out of every 20 female cancer diagnoses worldwide in 2018; the etiology of this disease is not well understood, and preventive programs are not established. It is well known that thyroid cancer incidence has been increasing…
FatPlants: A Comprehensive Website Platform of Plant Fat Related Genes, Proteins and Metabolism
Increasing seed oil content by plant breeding has resulted in trade-offs or penalties with respect to protein content, seed size, or seed set. The molecular basis for this impasse is mostly speculative. Use of current global profiling approaches to better…
Cancer Surveillance Informatics – Missouri Cancer Registry and Research Center
Cancer surveillance has to be able to monitor trends of cancer cases, subtypes of cancer, and cancer clusters to inform cancer control and policies related to cancer and cancer care. The increasing complexity and depth of cancer care, treatment, and…
Development of A Blockchain Framework for Virtual Clinical Trials
Clinical trials are essential for discovering new treatments, but there are multiple challenges to patient recruitment, patient engagement, and cost containment. Virtual clinical trials (VCT) are an innovative approach that provides potential solutions by conducting home-based, rather than site-based, clinical…
Identifying Patient-specific Flow of Signal Transduction Perturbed by Multiple Single-nucleotide Alterations
Background: Identifying patient-specific flow of signal transduction perturbed by multiple single-nucleotide alterations is critical for improving patient outcomes in cancer cases. However, accurate estimation of mutational effects at the pathway level for such patients remains an open problem. While probabilistic pathway…
Analysis of Healthy Coping Feedback Messages from Diabetes Mobile Apps
To analyze Healthy Coping-related feedback messages from diabetes mobile apps against the theoretical framework based on behavioral change theories. We searched apps using the search terms: “diabetes,” “blood sugar,” “glucose,” and “mood” from iTunes and Google Play stores. We entered…
Data-Driven Patients Stratification and Drug Repositioning
Cancer is a heterogeneous disease and represents a great example of the need for selecting patient-centric rather than disease-centric treatment. De novo drug discovery is a time-consuming and high-cost process with a low success rate. Drug repositioning (DR) reduces the…
Data Analytics Using the Cerner Real-world COVID-19 Data to Answer Clinical Questions
Cerner Real World data allows researchers and data scientists to explore clinical data via HealtheDataLab. Recently, Cerner granted many of their client institutions access to de-identified patient’s data for COVID-19 research to help fight the pandemic. The de-identified patient data…
Improving interpretation of Genome-Wide Association Studies (GWAS) by quantifying Marker Recurrence
To understand biological differences within groups of people or animals, we often turn to DNA. A genome-wide association study (GWAS) can assess the genetic contribution of biological differences between individuals. However, the scale of input data continues to expand in…