Diabetes Self-Management Applications: Focus Group Findings from Elderly Diabetic Patients
The number of mobile diabetes self-management (DSM) apps has risen. However, it is not certain whether these apps provide effective DSM for elderly diabetic patients. The purpose of this study was to identify barriers in functionality and usability related to…
Botanical treatments to inhibit endometriosis: A next generation RNA-seq data analysis
Endometriosis is a benign but complex gynecologic disorder associated with pelvic pain and infertility and is characterized by the implantation of endometrial tissue outside of the uterus. To date, the reason remains unknown, though the immune dysfunction has been implicated.
Mining for epigenetic patterns across species
Exponential growth of next-generation sequencing technologies has made the epigenomics analysis a big data science, which poses the challenges to its translation into knowledge. This has led to the emergence of a new field called “Comparative Epigenomics.” Comparative epigenomics has…
Sequence mining of EMR log data to understand clinician workflow
Modeling clinical workflow is an important pre-cursor to understanding how clinicians interact with an EMR and its features. Common methods of assessing clinical workflow include video recording or direct observations, or through directed user experience testing in a controlled environment.
Transformation of the advance care planning process through the use of an online computer-assisted instruction program and electronic health record enhancements at the University of Missouri
The Institute of Medicine report (1997) defines a good death as “good care at the end of life…depend[ant] on strong interpersonal skills, clinical knowledge, and technical proficiency, and it is informed by scientific evidence, values, and personal and professional experience”…
Visualization of Female Breast Cancer Burden in Missouri
Background: In 2011, the female breast cancer incidence rate was about 120 per 100,000 population and the mortality rate was 24 per 100,000 population in Missouri. There is a critical need to build fact sheets in the form of interactive…
Baby Genomics: Tracing the Evolutionary Changes That Gave Rise to Placentation
It has long been a challenge to determine the genetic origin of new characters in the evolution. The molecular mechanisms behind many morphological innovations are still unknown, including such striking evolutionary transitions as the appearance of the placenta. Our approach…
A Computational Pipeline for Comparative Study of Guide RNAs for CRISPR-CAS Genome Editing Systems
CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats- CRISPR Associated Proteins ) systems were recently developed into genome editing tools. Given their strength in multiplex targeting and easy programmability, CRISPR-CAS systems are already widely applied in academia and industry. While existing detection approaches could capture…
A Deep Neural Network Method for Predicting Mitochondria-Localized Proteins in Plants
Targeting and translocation of proteins to the appropriate subcellular compartments is crucial for cell organization and function. Newly synthesized proteins are transported to mitochondria with the assistance of targeting sequences, which are complex, containing either an N-terminal presequence or a…