Botanical treatments to inhibit endometriosis: A next generation RNA-seq data analysis

Endometriosis is a benign but complex gynecologic disorder associated with pelvic pain and infertility and is characterized by the implantation of endometrial tissue outside of the uterus. To date, the reason remains unknown, though the immune dysfunction has been implicated. Hormonal interventions are widely used as effective treatment but with undesirable side effects. Botanical treatments can be alternative options with fewer side effects. In this study, we employed RNA-seq technology to assess the effects of two different botanical treatments, quercetin, and elderberry juice over vehicle (control), to inhibit the growth of endometriotic lesions in a mouse model (C57BL/6) of endometriosis. In this seminar, the informatics approach for the data analysis will be presented.