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Abnormal liver function and adverse health outcomes in COVID-19: A multicenter, retrospective analysis of 14,872 patients from the Cerner Real-World DataTM de-identified COVID-19 cohort

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been associated with liver impairment and abnormalities in liver function tests.  However, associations between hepatic impairment and patient health outcomes have not been well-studied in large cohorts.  In this US-based, multicenter retrospective cohort study, we analyze the impact of abnormalities in liver function

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Methods for Measuring Geodiversity in Large Overhead Imagery Datasets

This research introduces some of the first geo-computational methods to address a key gap in the artificial intelligence (AI) and big data literature as it relates to the geosciences and remote sensing: the lack of understanding of the global feature representativeness of labels in large remotely-sensed imagery (RSI) datasets. Issues of data fairness, heterogeneity and

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The Genescape Allele Catalog Development for Precise Identification of Causative SNPs

Next-generation sequencing (NGS) has become more popular in the modern-day. Large amounts of next-generation resequencing data have been generated and are available online for various organisms including soybeans. However, current genome-wide association study (GWAS) prediction tools simply identify the most significant SNP based on Manhattan plots and still have some limitations in pinpointing the exact

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Evaluating the effectiveness of transfer-learning with DeepVariant

Genomic data has become ubiquitous for bioinformaticians; however, successfully inferring biological meaning depends upon the sensitive prediction of differences between genomes. The most popular method to infer short sequence variants is the Genome Analysis Toolkit (GATK). While GATK provides rigorous guidelines, the methods require knowledge-intensive refinement as software and sequencing technologies advance. A recent advancement

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Tool Development for Analyzing Arrhythmias in Fast Cardiac Magnetic Resonance Scans

Cardiac magnetic resonance (CMR) scanning provides a method to diagnose cardiac disease. For obtaining an effective image, the standard procedure of CMR requires patients to hold their breath during the scanning, but it is difficult for frail patients in clinic. Furthermore, standard CMR imaging depends upon averaging together regular cardiac cycles, which is disrupted by

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Early Detection of Glaucoma Using Electronic Health Records

Glaucoma is the second leading cause of irreversible blindness worldwide. About 70 million people have glaucoma, and nearly 4.4 million people are blind from optic nerve damage due to undiagnosed glaucoma. Besides, the current glaucoma growth rate and its economic burdens are unsustainable. As a result, warrant a systematic evaluation for glaucoma risk assessment and

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Evaluation of chronic disease self-management information on social media using evidenced-based frameworks

The management of chronic diseases requires considerable patient education and self-management. Diabetes, cancer and mental illness are among the top ten searched chronic diseases on social media, a platform where people increasingly seek and disseminate information. Social media platforms such as Twitter can potentially shape online conversations and perceptions about chronic disease management. In this

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Analysis of snRNA-seq from CDX Models of Non-Small Cell Lung Cancer Identified Subpopulation of Cells Potentially Responsible for Tumor Progression

Circulating tumor cells (CTCs) are considered as seeds of metastasis and have potential to be used as biomarkers in cancer.  Understanding the biology of CTCs is critical to evaluate tumor progression and response to treatment. Additionally, studying transcriptome of CTCs–derived tumors aids in deciphering the causes underlying metastasis. Single nuclei-RNA-sequencing (snRNA-seq) is an emerging technology that

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What to Learn and What to Avoid from ClinicalTrials.gov for New Trial Design When Repurposing Drugs for Precision Medicine?

Clinical trials are essential in the process of new drug development and repositioning. As clinical trials involve significant investments of time and money, it is crucial for trial designers to carefully investigate trial settings prior to launching it. In the 356,282 trials registered on ClinicalTrials.gov , one can search similar trial setting with the current

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A Case-Control based Genomic Analysis of Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease (COPD) is a respiratory illness that affects millions of people all over the world. It is a major cause of chronic morbidity and mortality and a serious global public health problem. COPD is the fourth leading cause of death worldwide. Although the environmental causes of COPD which predominantly include cigarette smoking

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