A Novel Approach to Antigen-reactive T Cell Identification
T cells are instrumental in orchestrating cell-mediated adaptive immunity by their unique ability to recognize antigens via T cell receptors (TCRs) and initiate downstream immune responses. TCRs exhibit an astonishing degree of variability, surpassing numbers of T cells within an…
Iterative Prompt Refinement for Mining Gene Interactions from ChatGPT
In recent years, the prowess of large language models (LLMs) like ChatGPT by OpenAI has garnered immense attention, not just for their raw computational abilities, but also for their potential as surrogate knowledge graphs. Trained on a plethora of data…
Identifying Genetic Variants Associated With Sex Specific Protective Effects In Autism Spectrum Disorder Using Adaptive Complexity Deep Neural Networks
Evaluating Benchmark Models with Multi-Omics Approaches for Long-Term Survival (LTS) Prediction Across 23 Cancer Studies
Cancer is a major cause of global mortality, necessitating accurate long-term survival (LTS) predictions for patients to optimize treatment strategies and improve prognosis. The advent of high-throughput technologies has facilitated the study of biological systems through multiple omics data, including…
Prototyping a Web-based Interface of Sensor Technologies for Remote Care Coordination and Self-management
The widespread adoption of consumer sensor technologies, including wearable and in-home sensors, present an opportunity for ambient monitoring of activities of daily living for health and behavioral intervention. Health care professionals (i.e., care coordinators trained as nurses, occupational therapists, and…
Relationships Between Mortality and Respiratory Health, Medication Usage, Water Disappearance, and Climatic Conditions in Commercial Weaning-To-Finishing Pigs
Mortality in pigs is of paramount economic importance to United States pig producers. According to data compiled by MetaFarms SMS and Pork Checkoff in 2022, 21.2% of pigs die before reaching slaughter, and this statistic has increased, in general, over the…
Enhancing Single Cell RNA-seq Analysis and Annotation for Understanding the Impact of CD137 Agonist on Cancer Immunoprevention through Advanced Informatics Algorithms
SA-4-1BBL, a novel CD137 receptor agonist, has been generated by our group and selected as a promising candidate for preventing cancer progression in research. The SA-4-1BBL demonstrates notable immunoprevention efficacy in diverse tumor models when utilized as a treatment in…
Relationships between mortality and respiratory health, medication usage, water disappearance, and climatic conditions in commercial weaning-to-finishing pigs
Mortality in pigs is of paramount economic importance to United States pig producers. According to data compiled by MetaFarms SMS and Pork Checkoff in 2022, 21.2% of pigs die before reaching slaughter, and this statistic has increased, in general, over the…
Enhancing Single Cell RNA-seq Analysis and Annotation for Understanding the Impact of CD137 Agonist on Cancer Immunoprevention through Advanced Informatics Algorithms
SA-4-1BBL, a novel CD137 receptor agonist, has been generated by our group and selected as a promising candidate for preventing cancer progression in research. The SA-4-1BBL demonstrates notable immunoprevention efficacy in diverse tumor models when utilized as a treatment in…