Transformation of the advance care planning process through the use of an online computer-assisted instruction program and electronic health record enhancements at the University of Missouri
The Institute of Medicine report (1997) defines a good death as “good care at the end of life…depend[ant] on strong interpersonal skills, clinical knowledge, and technical proficiency, and it is informed by scientific evidence, values, and personal and professional experience”…
Visualization of Female Breast Cancer Burden in Missouri
Background: In 2011, the female breast cancer incidence rate was about 120 per 100,000 population and the mortality rate was 24 per 100,000 population in Missouri. There is a critical need to build fact sheets in the form of interactive…
Baby Genomics: Tracing the Evolutionary Changes That Gave Rise to Placentation
It has long been a challenge to determine the genetic origin of new characters in the evolution. The molecular mechanisms behind many morphological innovations are still unknown, including such striking evolutionary transitions as the appearance of the placenta. Our approach…
A Computational Pipeline for Comparative Study of Guide RNAs for CRISPR-CAS Genome Editing Systems
CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats- CRISPR Associated Proteins ) systems were recently developed into genome editing tools. Given their strength in multiplex targeting and easy programmability, CRISPR-CAS systems are already widely applied in academia and industry. While existing detection approaches could capture…
A Deep Neural Network Method for Predicting Mitochondria-Localized Proteins in Plants
Targeting and translocation of proteins to the appropriate subcellular compartments is crucial for cell organization and function. Newly synthesized proteins are transported to mitochondria with the assistance of targeting sequences, which are complex, containing either an N-terminal presequence or a…
An embarrassingly parallel application: High accuracy mapping of copy number variable regions
Finding gene copy number variation in a species is the cornerstone of genomic research. Most CNV finding tools and methods rely on comparing samples to the reference genome and on detecting certain signatures in the alignment data. These methods are…
Measuring the Speed and Efficacy of Clinical Decision Making through Medication History Visualizations
The rapid advancements in our ability to store, extract, and analyze data in the 20th and 21st century is overwhelming care providers. Large, diverse, complex and/or longitudinal datasets are continuously generated from a variety of instruments, sensors and/or computer-based transactions. …
Identification of the causal mutation for a congenital limb abnormality in Mediterranean river buffalo
Mediterranean river buffalo have recently undergone strong selection for increased quality and quantity of milk for mozzarella cheese production. Strong selection for traits such as milk production are often associated with increased inbreeding, leading to decreased genetic diversity and an…
Promoting Population Health Through mHealth: Can Personal Health Management System Alter Personal Health Behavior?
Abstract: mHealth provides unprecedented medium to collect valuable information on patients, which was otherwise hard to collect and incorporate into management decision making. Several interventions conducted by a leading university school of medicine to measure the health outcome of its…