Oct. 23, 2019
Evaluation of Provider Documentation Patterns as a Tool to Deliver Ongoing Patient-Centered Diabetes Education and Support
Diabetes is one of the most common chronic diseases in the world. As a disease with long term complications requiring changes in management, it requires ongoing diabetes self-management education and support (DSME/S). In the United States, however, only a small proportion of people with diabetes receive DSME/S. The diabetes education that providers deliver during follow up visits may be an important source for DSME/S. We collected 200 clinic notes for 100 adults with diabetes and studied the History of Present Illness (HPI) and Impression and Plan (I&P) sections. Using a codebook based on the seven principles of American Association of…
Oct. 23, 2019
Drug Repositioning for Subgroup discovery and Precision Medicine Implementation
Drug discovery is a high-cost, time-consuming, and labor-intensive process. With the declined approval rate for new drugs by the FDA, developing drug repositioning frameworks becomes crucial for improving patient care. Drug repositioning, known as old drugs for new uses, is an effective strategy to find new indications for existing drugs and is highly efficient, low-cost, and less risk. The proposed work is a network-based computational approach for subgroup cohort drug repositioning. Precision medicine is getting more attention to be applied in today’s healthcare system toward a more patient-centered system rather than a disease-based one. The phenotypic and genotypic variation among…
Oct. 22, 2019
MUIDSI Core Faculty Member, Dr. Laura Schopp, PIs Grant Helping Rural Areas
Dr. Laura Schopp, professor and chair of health psychology, received a $1.2 million grant from the US Health Resources and Services Administration to help fight the opioid epidemic. Read more……
Oct. 22, 2019
MUIDSI Core Faculty Member Blake Meyers Named Editor-in-Chief of “The Plant Cell”
Rockville, Maryland, October 21, 2019 – The American Society of Plant Biologists (ASPB) is pleased to announce the appointment of Blake C. Meyers to serve as editor-in-chief of The Plant Cell beginning January 1, 2020. Read More…
Oct. 16, 2019
Hierarchical agglomerative clustering of eusocial bee proteins
The assembly and annotation of the European Honey bee (Apis mellifera) genome has predicted more than 15,000 protein-coding genes and became the foundation for studies of nature and evolution of eusociality. Since then, other eusocial bee genomes have been sequenced, providing an excellent opportunity to seek additional insight into unique traits of eusocial bees at the genomic and proteomic level. We wish to build a non-redundant organization of protein sequences by applying an unsupervised hierarchical protein-clustering method to the protein sequences of 4 advanced eusocial honey bees and 2 primitively eusocial bumblebees. The clustering method will group proteins into clusters…
Oct. 8, 2019
Mutational Forks: Inferring Pathway Deregulation Based on Patient-Specific Genomics Profiles
The precise mechanism behind treatment resistance in cancer is still not fully understood. Despite advances in precision oncology, there is a lack of the tools that help to understand a mechanistic picture of treatment resistance in cancer patients. Existing enrichment methods heavily rely on quantitative data and limited to analysis of differentially expressed genes, ignoring crucial players that might be involved in this process. In order to tackle treatment resistance, the identification of deregulated flow of signal transduction is critical. Here, we introduce a bioinformatics framework that is capable of inferring deregulated flow of signal transduction given evidence-based knowledge about…
Oct. 2, 2019
LARGE-SCALE SOYBEAN GENOME-WIDE VARIATION WORKFLOW AND ASSOCIATION ANALYSIS USING DEEP LEARNING
With the advances in next-generation sequencing technology and significant reduction in sequencing costs, it is now possible to sequence large collections of germplasm in crops for detecting genome-scale genetic variations, and apply the knowledge towards improvements in traits. To facilitate large-scale NGS resequencing data analysis of genomic variations efficiently, we developed a systematic solution using high-performance computing environment, cloud data storage resources and graphics processing unit computing with cutting-edge deep learning approach. The solution contains an integrated and optimized variant calling workflow called ‘PGen’, a quantitative phenotype prediction model using convolutional neural network and an algorithm to study genome-wide association…
Oct. 1, 2019
Extension of the informatics framework for the structurization of free text diagnostic reports
In this seminar presentation, we will briefly discuss our recent project to extend our informatics pipeline for the structurization of free-text diagnostic reports with an information theory-based approach. We will focus on the steps of this approach that are for quantifying and measuring information in free text diagnostic reports. This is a work in progress.
Sep. 24, 2019
Analysis of Curated Toll-Like-Receptor Co-expression Network Reveals associations among RNAseq Expression and Immune system modulation in patients with Colorectal Cancer
This project is concerned with improving immune system capabilities in the context of immunotherapy for colorectal cancer treatments. Immunotherapies called checkpoint inhibitors are monoclonal antibody treatments that have been proven to be effective in small percentages of sample populations, especially upon a combination of treatments (e.g. PD-1 with CTLA-4). However, the effectiveness of the treatment response often accompanied by contraindications of autoimmunity. Allocation of our efforts towards computational modeling of communication networks specific to TLR signaling affords a more intimate study of innate immunity, and the corresponding responses generated, as they pertain to the Tumor Microenvironment. Targeting the mechanisms…