MUIDSI Dissertation Defense: IDENTIFICATION OF IMMUNE-RELATED GENE SIGNATURES TO EVALUATE IMMUNOTHARAPEUTIC RESPONSE IN CANCER PATIENTS USING EXPLORATORY SUBGROUP DISCOVERY

Phenotypic and genotypic heterogeneity are characteristic features of cancer patients. To tackle patients’ heterogeneity, immune checkpoint inhibitors (ICIs) represent one of the most promising therapeutic approaches. However, approximately 50% of cancer patients that are eligible for treatment with ICIs will not respond well, which motivates the exploration of immunotherapy in combination with either targeted treatments or chemotherapy. Over the years, multiple patient stratification techniques have been developed to identify homogenous patient subgroups, although, matching patient subgroup to treatment option that can improve patients’ health outcome remains a challenging task.  We extend our exploratory subgroup discovery algorithm to identify patient subpopulations…

MUIDSI DISSERTATION DEFENSE: Explainable Artificial Intelligence To Stratify Pan-Cancer Patients For Immune Checkpoint Inhibitor Decision Making

Immune checkpoints are a normal part of the immune system. It engages when proteins on the surface of immune cells called T cells recognize and bind to partner proteins on other cells, such as some tumor cells. Immune based therapies such as ICIs work by blocking checkpoint proteins from binding with their partner proteins. This prevents the “off” signal from being sent, allowing the T cells to kill cancer cells. One such drug act against a checkpoint protein called PD-1 or its partner protein PD-L1. Some tumors turn down the T cell response by producing lots of PD-L1. Recent years…

2022 Mizzou Faculty Alumni Awards – Notable Presence from MUIDSI

The 67th Annual Faculty Alumni Awardees were announced  on July 20, 2022.  Dr. Chi-Ren Shyu, MU IDSI Director; Dr. Lori Popejoy, MU IDSI Core Faculty and Interim Dean of Sinclair School of Nursing; and Dr. Dr. Stevan Whitt, Senior Associate Dean for Clinical Affairs of Medicine and MU IDSI’s long term physician collaborator, were among the six faculty awardees this year.  According to Mizzou Alumni Association, “First celebrated in 1968, the Faculty Alumni Awards highlight the contributions of exceptional individuals to the University’s growth and core mission, through their professional accomplishments, teaching and research excellence or service to the institution.” To…

Dr. Popejoy leads MU Sinclair School of Nursing as Interim Dean

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Dr. Blake Meyers Elected to the National Academy of Sciences

Dr. Blake Meyers, MUIDSI Informatics PhD program Core Faculty and Professor in the Division of Plant Science and Technology, and jointly appointed as a Principal Investigator and Member of the Donald Danforth Plant Science Center, has been elected as a Member of the US National Academy of Sciences.  https://www.danforthcenter.org/news/blake-meyers-elected-to-national-academy-of-sciences/

AMIA Informatics Summit Best Student Paper Award

By Karly Balslew On March 21st, doctoral student Humayera Islam won the American Medical Informatics Association (AMIA) Student Paper Competition award for the 2022 AMIA Informatics Summit that was held in Chicago. “It’s one of the biggest platforms for informatics people,” Islam said. “It’s very a very diverse and multidisciplinary platform where anybody that works in this area (informatics) can show their work.”  Students from across the country submitted papers for AMIA 2022 Informatics Summit. Submitted papers then went through a peer-review process before judges selected the top five best papers. These top five were chosen to compete in the…

MUIDSI Online Data Science and Analytics Program Ranked #7 in Fortune Magazine

The MS Data Science and Analytics (DSA) Program of the MU Institute for Data Science and Informatics (MUIDSI) was  recently ranked the 7th best online master’s degree in Data Science Programs in 2022 by Fortune magazine. The rankings were composed of a selectivity score and a demand score. The selectivity score made up 85% of the ranking which assessed undergraduate GPA of incoming students, the average years of work experience and the universities acceptance rate.  The demand score consisted of total enrollment size of the programs and the number of applicants for the most current year.  As data information continues to rapidly…

Harnessing the power of AI to advance knowledge of Type 1 diabetes

An interdisciplinary team of researchers from the University of Missouri, Children’s Mercy Kansas City and Texas Children’s Hospital has used a new data-driven approach to learn more about persons with Type 1 diabetes, who account for about 5-10% of all diabetes diagnoses. The team gathered its information through health informatics and applied artificial intelligence (AI) to better understand the disease. In the study, the team analyzed publicly available, real-world data from about 16,000 participants enrolled in the T1D Exchange Clinic Registry. By applying a contrast pattern mining algorithm developed at the MU College of Engineering, the team was able to…

Dissertation Defense – UNDERSTANDING GENOME COMPOSITION OF EUSOCIAL HYMENOPTERAN INSECTS

Genome sequencing of the Western honey bee (Apis mellifera), a model for the biology and evolution of eusocial behavior, has revealed unusual genome compositional characteristics, including a low but heterogeneous GC content, bimodal GC content distribution, and a biased tendency of genes to be located in low GC regions. In this dissertation, we sought to determine whether those features are specific to Apis or shared with other insects and the biological meaning of those features. Chapter 1 reviews the major concepts that tie my dissertation research together, highlighting the importance of recombination, GC composition, and their relationship to the evolution of eusociality.