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Although Blockchain is much more investigated within the financial sector, it is gradually edging into other industries such as healthcare. Blockchain provides a trust mechanism in a cyber-system. Various last mile issues left to be resolved for establishing an end to end trust cyber physical system. This talk will discuss various aspects of blockchain last mile issues applied in the medical area. Especially, for data integrity, trust and secure data sharing technology specially fit for precision medicine supporting patient centric healthcare model. This is an international collaboration project among Asia University, Taiwan, China Medical University Hospital, Taiwan, University of Missouri, USA, and National Institute of Health (NIH) USA.