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Integrated analysis of genomics, longitudinal metabolomics, and Alzheimer’s risk factors among 1,111 individuals

Although Alzheimer’s disease (AD) is highly heritable, genetic variants known to be associated with AD only explain a small proportion of its heritability. It is possible that some genetic factors only convey disease risk in individuals with certain environmental exposures, suggesting that a multi-omics approach could reveal the underlying mechanisms contributing to complex traits, such