Research in the Zezong Gu laboratory focuses on the studies of traumatic brain injury (TBI) and cerebral ischemia. This includes associated aging-related neurodegenerative diseases in animal models for mechanistic and translational investigations in aiding for the development of biomarkers, preventive and therapeutic strategies. The Gu laboratory uses multi‐disciplinary approaches and paradigms to conduct translational research. The Gu laboratory toolbox includes cell‐free protein interaction, primary neuron cultures including biofidelic 3D cultures, and in vivo rodent models of neurodegenerative diseases, as well as neurobehavioral assessment, digital pathology and quantitative proteomic analyses and bioinformatics. Ultimately, the endeavor of Dr. Gu’s studies supported with a number of cutting‐edge techniques and resources may lead to identifying potential biomarkers and therapeutic targets for neurodegenerative diseases. Dr. Gu is also passionate about the training of scientists, physicians, and graduate students from all over the world, which as of now includes Mexico, Puerto Rico, China, Indian, Japan, Philippines, Turkey, Israel, Libya, Cote D’lvoire, Ghana, Nigeria, Cameroon, and South Africa.