Scientific illustrations as a source of biological pathway information
The idea of cross-referencing distinct areas of knowledge to glean new insights is not new, but not much work has been done with automatic analysis of different expressions of the same knowledge source, such as a given scientific text and…
Synteny and compositional domains in honey bee genomes
Analysis of synteny, the conservation of gene order between homologs along chromosome segments, is a standard investigative strategy done in many comparative genomic studies to understand genomic conservation and evolution. It allows us to study the evolutionary history between genomes.
A Case-Control based Genomic Analysis of Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease (COPD) is a respiratory illness that affects millions of people all over the world. It is a major cause of chronic morbidity and mortality and a serious global public health problem. COPD is the fourth leading…
Large Scale Study of the Long-Term Effects of COVID-19 Infection Using Aggregated EHR Data
COVID-19 is known to have complex multi-system effects but the lasting effects of infection remain poorly understood. With the number of confirmed infections globally surpassing 200 million it is more important than ever to understand the potential long-term implications of…
FASTAptameR 2.0: A Web Server for Combinatorial Selections Analysis
Combinatorial selection strategies are powerful tools that allow researchers to simulate selective pressures over time on randomized sequence libraries. This is important for lead discovery and optimization and for understanding selection dynamics. Given the evolutionary nature of these experiments, high-fitness…
MD – Informatics PhD student, Cynthia Tang, wins the American College of Physicians 2021 National Virtual e-Poster Competition
Cynthia Tang is a first-year MD- Informatics PhD program student in Dr. Henry Wan’s lab. In her poster presentation “Assessing the clinical, epidemiological, and molecular implications of SARS-CoV-2 in Missouri”, Cynthia presented her research findings on SARS-CoV-2 viruses. In the May 14, 2021 American…
Bioinformatics Research and Collaboration in the Era of Big Data and Precision Medicine
As we have entered the precision medicine and big data science era, there are many unmet challenges on identifying the disease related information from large, heterogeneous data, and translating the findings for clinical use. Among these challenges, one is how…
Detection of changes in allelic frequencies due to selection on complex traits in the genomes of pigs from four genetic lines using generation proxy selection mapping
Most economically relevant traits in pig breeding programs are controlled by numerous causal variants spread across the genome and undergo selection pressure to improve the genetic merit of commercial pigs. As a result, small changes in allele frequency over relatively…
CANCER PRIORITY BY RACE
Cancer is one of the most common and deadly diseases and its incidence is increasing. There are over one hundred types of cancer and they have a varied impact on society and the individuals affected. Racial disparities play a role…