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Computational Subgroups Stratification and Precision Drug Repositioning Using Explainable Artificial Intelligence

Enabling precision medicine requires developing robust patient stratification methods and identifying drugs tailored to homogeneous subgroups of patients from a heterogeneous population. Once discovering these subgroups, we can align patients and medications more specifically to achieve precision-based therapy. Developing de novo drugs is expensive and time-consuming with an ultimately low FDA approval rate. These limitations make developing

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Comprehensive Exam Announcement – A Case-Control based Genomic Analysis of Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease (COPD) is a respiratory illness that affects millions of people all over the world. It is a major cause of chronic morbidity and mortality and a serious global public health problem. COPD is the fourth leading cause of death worldwide. Although the environmental causes of COPD which predominantly include cigarette smoking

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Thyroid Cancer Informatics

Survival prediction is important both to clinicians and patients; ensuring the best course of treatment is selected to manage the thyroid cancer. In 2018, there was an estimated half a million new thyroid cancer diagnoses and 41,071 deaths. Unlike other tumors whose mortality has decreased over the last two decades, thyroid cancer mortality rates have increased. Existing risk

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A Case-Control based Genomic Analysis of Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease (COPD) is a respiratory illness that affects millions of people all over the world. It is a major cause of chronic morbidity and mortality and a serious global public health problem. COPD is the fourth leading cause of death worldwide. Although the environmental causes of COPD which predominantly include cigarette smoking

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Using Big Data to Identify Possible External Risk Factors for Poorly Understood Cancers

Worldwide, cancer is the second leading cause of death (Cancer, 2012). There were 17 million new cases and 9.6 million cancer deaths worldwide in 2018, including approximately 1.7 million new U.S. cases and 600,000 U.S. cancer deaths (Cancer Facts & Figures 2018 | American Cancer Society, 2018; Worldwide Cancer Statistics, 2019). The worldwide incidence of cancer is expected to increase

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An Evaluation of Physician Burnout by EMR Use Characterization and Correlation

Burnout disproportionately affects healthcare workers and continues to rise.  This condition potentially contributes to cost, quality and patient safety risk in an already overburdened United States healthcare system.  While the causes of burnout are complex, evidence exists pointing to Electronic Medical Record use (EMR) as one major contributor due to the increased clerical burden that decreases patient

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