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Synteny and compositional domains in honey bee genomes


Hung Nguyễn







Analysis of synteny, the conservation of gene order between homologs along chromosome segments, is a standard investigative strategy done in many comparative genomic studies to understand genomic conservation and evolution. It allows us to study the evolutionary history between genomes. Conservation of synteny can reflect highly important regions in the genome or critical functional relationships between orthologous genes. Our recent study of genome compositional features of Hymenopteran provided insights into genomic compositional features of Apis and other insects with different levels of eusociality. To further understand the biological meaning of different GC regions within the honey bee genomes, we analyzed the relationship between synteny in the honey bee genomes and their compositional domains.Implementing MCscanX, an algorithm for detecting synteny from homology information, we identified syntenic blocks across genomes of 9 species in Apinae sub-family (corbiculate bee). Using compositional domains information, we calculated the probability of being in the same domain and the same syntenic block together. We discovered that there is a relationship between synteny and compositional domain in (Honey bee) species. Statistically, genes in the same syntenic block are also likely to be in the same domain. Additionally, genes in the low GC domain are much more likely to be in the syntenic blocks.

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