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REDESIGN: RDF-based Differential Signaling Framework for Precision Medicine Analytics

Presenter:

Zainab Al-Taie

Date:

02-26-2018

Time:

11:00AM-12:00PM

Location:

2206A Student Center

Pathway-based analysis holds promise to be instrumental in precision and personalized medicine analytics. However, the majority of pathway-based analysis methods utilize “fixed” or “rigid” data sets that limit their ability to account for complex biological inter-dependencies. Here, we present REDESIGN: RDF-based Differential Signaling Pathway informatics framework. The distinctive feature of the REDESIGN is that it is designed to run on “flexible” ontology-enabled data sets of curated signal transduction pathway maps to uncover high explanatory differential pathway mechanisms on gene-to-gene level. The experiments on two morphoproteomic cases demonstrated REDESIGN’s capability to generate actionable hypotheses in precision/personalized medicine analytics.