The US National Center for Health Statistics estimated that more than 19 million adults in the US have ever been diagnosed with cancer. Chemotherapy is one of the important modality of cancer treatments. Chemotherapy-Induced Nausea and Vomiting (CINV) are the two most dreadful and unpleasant side effects of chemotherapy. CINV substantially degrades the patients’ life quality (due to dehydration, nutritional deficits, electrolyte imbalance, etc.) and increases the healthcare cost (by requiring further management of CINV including outpatient visits, drugs, hospitalization, etc.). In addition, cancer patients sometimes discontinue chemotherapy due to intolerable CINV. Thus, this is imperative to identify and treat the patients at high-risk of CINV before chemotherapy. In this presentation, the development of a decision support software for improving the prevention of CINV will be discussed.